Macromolecular Prodrugs Based on Synthetic Polyaminoacids: Drug Delivery and Drug Targeting in Antitumor Therapy

Title: Macromolecular Prodrugs Based on Synthetic Polyaminoacids: Drug Delivery and Drug Targeting in Antitumor Therapy

Volume: 11 Issue: 18

Author(s): Gennara Cavallaro, Giovanna Pitarresi and Gaetano Giammona

Affiliation:

Keywords: alpha,beta-poly(N-2-hydroxyethyl)-DL-aspartamide, alpha,beta-polyaspartylhydrazide, poly(glutamic acid), carriers, anticancer drugs, pharmaceutical field, nanostructured materials, nanotechnologies, drug molecule, polymeric micelles, chemical conjugation, polyaminoacids, thermal polycondensation, polyaspartic acid (PAA), systematic studies, aα,β:-poly(N-2-hydroxyethyl)-DL-aspartamide, α,β:-polyaspartylhydrazide

Abstract: In the last twenty years a depth study on potential pharmaceutical applications of synthetic polymers at proteinlike structure as carrier for macromolecular prodrug production has been performed in academia and in industry. In particular α,β-poly(N-2-hydroxyethyl)-DL-aspartamide (PHEA), α,β-polyaspartylhydrazide (PAHy), poly(glutamic acid) (PGA), poly(aspartic acid) (PAA) and polylysine (PLL) have been extensively studied in this field. In the present review, the use of PHEA, PAHy, PGA as starting materials to prepare macromolecular prodrugs is reported and drug delivery and targeting aspects have been considered.

Cite this article as:

Cavallaro Gennara, Pitarresi Giovanna and Giammona Gaetano, Macromolecular Prodrugs Based on Synthetic Polyaminoacids: Drug Delivery and Drug Targeting in Antitumor Therapy, Current Topics in Medicinal Chemistry 2011; 11 (18) . https://dx.doi.org/10.2174/156802611797183276