C-Abl Tyrosine Kinase Signaling: A New Player in AD Tau Pathology

Title: C-Abl Tyrosine Kinase Signaling: A New Player in AD Tau Pathology

Volume: 8 Issue: 6

Author(s): L. D. Estrada, S. M. Zanlungo and A. R. Alvarez

Affiliation:

Keywords: Alzheimer, tau, phosphorylation, c-Abl, Aging, dementia, genetic epidemiology, metabolism, obesity, twins, predisposing effect, genetic allele, memory impairment, BMI, MET, TICS, TELE

Abstract: Hyperphosphorylated tau is a cardinal feature of Alzheimers disease (AD) pathology. The deregulation of kinases that phosphorylate tau can alter normal tau-related processes, including microtubule dynamics, growth cones, and axonal transport, and induce tau aggregation in paired helical filaments. Here we discuss the possible roles of the Abl family of tyrosine kinases, which are essential regulators of cytoskeleton cellular signaling cascades, in AD tau pathology and how the physiological roles of Abl kinases could be connected with the cytoskeletal alterations induced by Aβ aggregates and AD progression.

Cite this article as:

D. Estrada L., M. Zanlungo S. and R. Alvarez A., C-Abl Tyrosine Kinase Signaling: A New Player in AD Tau Pathology, Current Alzheimer Research 2011; 8 (6) . https://dx.doi.org/10.2174/156720511796717249