Synthesis and Biological Activity of Phosphonated Nucleosides: Part 1Furanose, Carbocyclic and Heterocyclic Analogues

Anna      Piperno; Maria   A.   Chiacchio; Daniela      Iannazzo; Roberto      Romeo

doi:10.2174/092986706779026110

Abstract

Phosphonated nucleosides represent a promising alternative in the improvement of the biological activity of nucleoside analogues in antiviral and anticancer chemotherapy. The basic concept, the chemistry, the different structural modifications and their effects on the antiviral potency will be discussed in this review.

Keywords: Nucleotides, phosphonates, antiviral, nucleosides, anti-herpes, anti-HIV, nucleic acids

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Current Medicinal Chemistry

Title: Synthesis and Biological Activity of Phosphonated Nucleosides: Part 1Furanose, Carbocyclic and Heterocyclic Analogues

Volume: 13 Issue: 30

Author(s): Anna Piperno, Maria A. Chiacchio, Daniela Iannazzo and Roberto Romeo

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Keywords: Nucleotides, phosphonates, antiviral, nucleosides, anti-herpes, anti-HIV, nucleic acids

Abstract: Phosphonated nucleosides represent a promising alternative in the improvement of the biological activity of nucleoside analogues in antiviral and anticancer chemotherapy. The basic concept, the chemistry, the different structural modifications and their effects on the antiviral potency will be discussed in this review.

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Piperno Anna, Chiacchio A. Maria, Iannazzo Daniela and Romeo Roberto, Synthesis and Biological Activity of Phosphonated Nucleosides: Part 1Furanose, Carbocyclic and Heterocyclic Analogues, Current Medicinal Chemistry 2006; 13 (30) . https://dx.doi.org/10.2174/092986706779026110