Mechanisms at the Interface of Innate and Adaptive Immunity in the Pathogenesis of RSV Disease: Lessons from the Mouse Model

Title: Mechanisms at the Interface of Innate and Adaptive Immunity in the Pathogenesis of RSV Disease: Lessons from the Mouse Model

Volume: 7 Issue: 3

Author(s): Anne Ilchmann and Jurgen Schwarze

Affiliation:

Keywords: Respiratory sycytial virus, bronchiolitis, mouse models, epithelial cells, dendritic cells, macrophages, Immunity, vaccine, Inflammatory, pathogens

Abstract: Respiratory syncytial virus (RSV) disease is a serious health concern in young children, immunocompromised adults and the elderly. No vaccine or specific treatment is currently available and to develop these, a more thorough understanding of the immune mechanisms of RSV-induced inflammation is required. Studies in mouse models have provided valuable insights and this review aims to provide a concise summary of recent findings on patho-mechanisms at the interface of innate and adaptive immunity. We discuss the role of epithelial cells, macrophages and dendritic cells as well as toll like receptor signalling in RSV-induced airway inflammation and compare data from mouse models with observations from studies in human cells and patients, where available.

Cite this article as:

Ilchmann Anne and Schwarze Jurgen, Mechanisms at the Interface of Innate and Adaptive Immunity in the Pathogenesis of RSV Disease: Lessons from the Mouse Model, Current Respiratory Medicine Reviews 2011; 7 (3) . https://dx.doi.org/10.2174/157339811795589478