Synthesis of N-glycopeptides Applying Glycoamino Acid Building Blocks with a Combined Fmoc/Boc Strategy

Title: Synthesis of N-glycopeptides Applying Glycoamino Acid Building Blocks with a Combined Fmoc/Boc Strategy

Volume: 18 Issue: 7

Author(s): Kinga Rakosi, Orsolya Szolomajer-Csikos, Laszlo Kalmar, Zoltan Szurmai, Janos Kerekgyarto and Gabor K. Toth

Affiliation:

Keywords: Carbohydrates, Boc deprotection, N-glycopeptides, solid-phase synthesis, tin(IV) chlorideCarbohydrates, Boc deprotection, N-glycopeptides, solid-phase synthesis, tin(IV) chloride

Abstract: Mono-, di- and trisaccharide representing the reducing terminal of the core structure of N-glycans were incorporated into Leu-Lys-Asn-Gly-Gly-Pro hexapeptide that is a partial structure of the Trp-cage mini-protein by linear assembly. These studies provide evidence that the used combination of Fmoc and Boc strategy and mild conditions result in glycopeptides in high purity and reasonable yield.

Cite this article as:

Rakosi Kinga, Szolomajer-Csikos Orsolya, Kalmar Laszlo, Szurmai Zoltan, Kerekgyarto Janos and Toth Gabor K., Synthesis of N-glycopeptides Applying Glycoamino Acid Building Blocks with a Combined Fmoc/Boc Strategy, Protein & Peptide Letters 2011; 18 (7) . https://dx.doi.org/10.2174/092986611795446003