Salicylanilides and Their Derivates as Perspective Anti-tuberculosis Drugs: Synthetic Routes and Biological Evaluations

Title: Salicylanilides and Their Derivates as Perspective Anti-tuberculosis Drugs: Synthetic Routes and Biological Evaluations

Volume: 8 Issue: 2

Author(s): Ales Imramovsky, Karel Pauk, Vladimir Pejchal and Jiri Hanusek

Affiliation:

Keywords: Anti-MDR tuberculotics, anti-tuberculotic agents, hydroxybenzamides, salicylanilides, salicylanilide derivates, pharmacological compounds, antifungal, antimicrobial

Abstract: Salicylanilides are a well-known family of pharmacological compounds, which are under renewed investigation because of the discovery of novel interesting biological activities and mechanisms of action over the last decade. This comprehensive mini-review describes the biological and pharmacological properties of salicylanilides, their activity against atypical and multi-drug resistant mycobacterial strains, and synthetic routes for their preparation. In particular, this review focuses on the synthesis and biological properties of salicylanilides and O-substituted derivates reported between 2000 and 2010, which have displayed the highest antituberculosis or antifungal activity.

Cite this article as:

Imramovsky Ales, Pauk Karel, Pejchal Vladimir and Hanusek Jiri, Salicylanilides and Their Derivates as Perspective Anti-tuberculosis Drugs: Synthetic Routes and Biological Evaluations, Mini-Reviews in Organic Chemistry 2011; 8 (2) . https://dx.doi.org/10.2174/157019311795177808