Efficient One-Pot Formation of Substituted γ-Amino Acids

Mardia      T. El-Sayed; Muhammad      Abbas; Andreas      Hilgeroth

doi:10.2174/157017811795685081

Abstract

A series of novel substituted γ-amino acids has been catalytically prepared by a one-pot reaction of substituted imines and homoenolates. The efficiency of the novel direct route has been found to depend on the nature of amine being either aliphatic or aromatic. Additionally, the influence of aromatic substituents has been investigated.

Keywords: γ-amino acid, homoenolate, imines, lewis acid, peptidases, homoaldol reaction, hydroxy, carbonyl, biodegradation, homoenolates

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Letters in Organic Chemistry

Title: Efficient One-Pot Formation of Substituted γ-Amino Acids

Volume: 8 Issue: 5

Author(s): Mardia T. El-Sayed, Muhammad Abbas and Andreas Hilgeroth

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Keywords: γ-amino acid, homoenolate, imines, lewis acid, peptidases, homoaldol reaction, hydroxy, carbonyl, biodegradation, homoenolates

Abstract: A series of novel substituted γ-amino acids has been catalytically prepared by a one-pot reaction of substituted imines and homoenolates. The efficiency of the novel direct route has been found to depend on the nature of amine being either aliphatic or aromatic. Additionally, the influence of aromatic substituents has been investigated.

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T. El-Sayed Mardia, Abbas Muhammad and Hilgeroth Andreas, Efficient One-Pot Formation of Substituted γ-Amino Acids, Letters in Organic Chemistry 2011; 8 (5) . https://dx.doi.org/10.2174/157017811795685081