Chemical and Pharmacological Significance of Natural Guanidines from Marine Invertebrates

Title: Chemical and Pharmacological Significance of Natural Guanidines from Marine Invertebrates

Volume: 11 Issue: 3

Author(s): S. S. Ebada and P. Proksch

Affiliation:

Keywords: Guanidine, marine invertebrates, antimicrobial, antiproliferative, anticoagulant, secondary metabolites, analgesic, Acyclovir, ziconotide, chronic pain, conotoxin MVIIA, Prialt®, Zovirax®

Abstract: Natural Guanidines from marine invertebrates represent a group of bioactive secondary metabolites that revealed prominent pharmacological activities such as antimicrobial, antiproliferative, analgesic, and anticoagulant properties. Acyclovir (Zovirax®), the first guanidine-derived pharmaceutical for the treatment of herpes infections since late 1970s, was synthesized based on a marine arabinosyl nucleoside, spongosine. Recently, ziconotide (Prialt®), a synthetic form of the marine-derived peptide (ω-conotoxin MVIIA) comprising a guanidine moiety, has been approved for the treatment of chronic pain. This review surveys over 130 compounds of guanidine-containing secondary metabolites from marine invertebrates with emphasis on their pharmacological significance and structure-activity relationships.

Cite this article as:

S. Ebada S. and Proksch P., Chemical and Pharmacological Significance of Natural Guanidines from Marine Invertebrates, Mini-Reviews in Medicinal Chemistry 2011; 11 (3) . https://dx.doi.org/10.2174/138955711795049862