Advances in the Analysis of Hepatitis C Virus Specific T Cell Responses

Title: Advances in the Analysis of Hepatitis C Virus Specific T Cell Responses

Volume: 11 Issue: 2

Author(s): Xinjian Zhang, Jun Dou and Markus W. Germann

Affiliation:

Keywords: Hepatitis C Virus (HCV), T cell, proliferation, tetramer, ELISpot, epitope mapping, Tetramer staining, flow cytometry, prophylactic HCV vaccines, Flaviviridae virus, Cytotoxicity T LymphocyTE (CTL) Assays

Abstract: There is a growing consensus that cellular immune responses are associated with the clinical outcome of hepatitis C virus infection (HCV). The development of Tetramer staining, ELISpot, flow cytometry and epitope mapping technologies makes it possible to enumerate, phenotype and assess the proliferation and function of HCV specific T cells; as well as map and predict T cell epitopes and track the evolution of T cell epitopes. Such information is essential for the development of effective therapeutic and prophylactic HCV vaccines. This article summarizes the technical advances relevant to HCV specific T cell responses.

Cite this article as:

Zhang Xinjian, Dou Jun and W. Germann Markus, Advances in the Analysis of Hepatitis C Virus Specific T Cell Responses, Mini-Reviews in Medicinal Chemistry 2011; 11 (2) . https://dx.doi.org/10.2174/138955711794519483