NH4Cl Mediated New Protocol for the Synthesis of 5-Arylidene Barbiturates

Khalid      Mohammed Khan; Muhammad      Ali; Momin      Khan; Muhammad      Taha; Shahnaz      Perveen

doi:10.2174/157017811794557778

Abstract

Eco-benign method for synthesizing arylidene barbiturates has been developed by using ammonium chloride (NH4Cl) in stoichiometric amount, as an enolization activator, in water. Execution of methodology is simple, products obtained in high yields and the reactions are completed within 30 min. The new methodology does not involve any solvent/solvent extraction while solid products were yielded in all cases which were filtered and washed.

Keywords: Barbituric acid, ammonium chloride, enolization activator, eco-friendly

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Letters in Organic Chemistry

Title: NH4Cl Mediated New Protocol for the Synthesis of 5-Arylidene Barbiturates

Volume: 8 Issue: 1

Author(s): Khalid Mohammed Khan, Muhammad Ali, Momin Khan, Muhammad Taha and Shahnaz Perveen

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Keywords: Barbituric acid, ammonium chloride, enolization activator, eco-friendly

Abstract: Eco-benign method for synthesizing arylidene barbiturates has been developed by using ammonium chloride (NH4Cl) in stoichiometric amount, as an enolization activator, in water. Execution of methodology is simple, products obtained in high yields and the reactions are completed within 30 min. The new methodology does not involve any solvent/solvent extraction while solid products were yielded in all cases which were filtered and washed.

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Mohammed Khan Khalid, Ali Muhammad, Khan Momin, Taha Muhammad and Perveen Shahnaz, NH4Cl Mediated New Protocol for the Synthesis of 5-Arylidene Barbiturates, Letters in Organic Chemistry 2011; 8 (1) . https://dx.doi.org/10.2174/157017811794557778