Microwave-Assisted Synthesis and Evaluation of Substituted Aryl Propyl Acridone-4-Carboxamides as Potential Chemosensitizing Agents for Cancer

Title: Microwave-Assisted Synthesis and Evaluation of Substituted Aryl Propyl Acridone-4-Carboxamides as Potential Chemosensitizing Agents for Cancer

Volume: 8 Issue: 3

Author(s): Vinaykumar S. Velingkar and Vikrant D. Dandekar

Affiliation:

Keywords: Aryl propyl acridone-4-carboxamides, Microwave, Chemosensitizing agents

Abstract: A novel class of compounds with structure Aryl propyl acridone-4-carboxamides were synthesized by conventional and microwave (MW) irradiation methods and evaluated for their inhibitory effects on the transport activity of P- glycoprotein (P-gp) by standard Hoechst 33342 assay method. The title compounds with phenoxy substitution exhibited better activity.

Cite this article as:

S. Velingkar Vinaykumar and D. Dandekar Vikrant, Microwave-Assisted Synthesis and Evaluation of Substituted Aryl Propyl Acridone-4-Carboxamides as Potential Chemosensitizing Agents for Cancer, Letters in Drug Design & Discovery 2011; 8 (3) . https://dx.doi.org/10.2174/157018011794578169