Synthetic Studies of Superstolide A: A Carbohydrate Based Synthesis of the C21-C26 Segment

Title: Synthetic Studies of Superstolide A: A Carbohydrate Based Synthesis of the C21-C26 Segment

Volume: 7 Issue: 8

Author(s): Rita Pal, Hasibur Rahaman, D. K. Mohapatra and Mukund K. Gurjar

Affiliation:

Keywords: Superstolide A, Potent cytotoxic, Chiral pool, Regioselective epoxide opening, Stereoselective hydroborationoxidation, Carbohydrate, C21-C26, Grignard reagent, Neosiphonia superstes, polyketide, D-glucose diacetonide, hydroboration oxidation, tosylation, alcohol, epoxidation, benzyl ether, Cleavage, methanolic HCl, hydroxyl group, Oxidative cleavage, CuCN, PDC oxidation, selectively, Debenzylation, BBN, PMB, mesylation, azido, compound

Abstract: The synthesis of C21-C26 fragment of superstolide A, starting from D-glucose diacetonide, involving regioselective ring opening of epoxide by Grignard reagent and regioselective stereospecefic hydroboration oxidation has been described.

Cite this article as:

Pal Rita, Rahaman Hasibur, K. Mohapatra D. and K. Gurjar Mukund, Synthetic Studies of Superstolide A: A Carbohydrate Based Synthesis of the C21-C26 Segment, Letters in Organic Chemistry 2010; 7 (8) . https://dx.doi.org/10.2174/157017810793811704