Abstract
Alzheimers disease is a form of sporadic, age-related dementia. According to the “amyloid hypothesis”, the processing of β-amyloid precursor protein (APP) leads to the formation of senile plaque aggregates which subsequently congest normal neurological functions. Currently, prophylaxis is testimonial, while treatment relies mainly on symptomatic relief. This review emphasizes the importance of disrupting the pathological processing of APP via α-secretase activators, β- and γ-secretase inhibitors, and compounds that bind APP. The style of writing should appeal to those with strong interests in medicinal chemistry with an equal balance of medicine and chemistry.
Keywords: Alzheimer's disease, amyloid peptide, drug development, inhibitor, secretase
Current Pharmaceutical Design
Title: Views on Amyloid Hypothesis and Secretase Inhibitors for Treating Alzheimers Disease: Progress and Problems
Volume: 12 Issue: 33
Author(s): Jeffrey-Tri Nguyen, Abdellah Yamani and Yoshiaki Kiso
Affiliation:
Keywords: Alzheimer's disease, amyloid peptide, drug development, inhibitor, secretase
Abstract: Alzheimers disease is a form of sporadic, age-related dementia. According to the “amyloid hypothesis”, the processing of β-amyloid precursor protein (APP) leads to the formation of senile plaque aggregates which subsequently congest normal neurological functions. Currently, prophylaxis is testimonial, while treatment relies mainly on symptomatic relief. This review emphasizes the importance of disrupting the pathological processing of APP via α-secretase activators, β- and γ-secretase inhibitors, and compounds that bind APP. The style of writing should appeal to those with strong interests in medicinal chemistry with an equal balance of medicine and chemistry.
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Cite this article as:
Nguyen Jeffrey-Tri, Yamani Abdellah and Kiso Yoshiaki, Views on Amyloid Hypothesis and Secretase Inhibitors for Treating Alzheimers Disease: Progress and Problems, Current Pharmaceutical Design 2006; 12 (33) . https://dx.doi.org/10.2174/138161206778792976
DOI https://dx.doi.org/10.2174/138161206778792976 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
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