Stereoselective Formal Synthesis of (-)-Salicylihalamides A and B Via Prins Cyclisation

J.S.      Yadav; N.      Venkateswar Rao; P.      Purushothama Rao; M.      Sridhar Reddy; A.R.      Prasad

doi:10.2174/157017810791824856

Abstract

A stereoselective and convergent formal approach to Salicylihalamide A and B is achieved through our recently developed strategy for the construction of polyketide precursors via Prins cyclisation. The approach mainly relies upon reductive opening of 1-iodomethyl cyclic ethers, Mitsunobu inversion and ring closing metathesis along with Prins cyclisation.

Keywords: Natural products, cytotoxicity, prins cyclisation, reductive cleavage, mitsunobu inversion, ring closing metathesis

« Previous Next »

Rights & Permissions Print Cite

Letters in Organic Chemistry

Title: Stereoselective Formal Synthesis of (-)-Salicylihalamides A and B Via Prins Cyclisation

Volume: 7 Issue: 6

Author(s): J.S. Yadav, N. Venkateswar Rao, P. Purushothama Rao, M. Sridhar Reddy and A.R. Prasad

Affiliation:

Keywords: Natural products, cytotoxicity, prins cyclisation, reductive cleavage, mitsunobu inversion, ring closing metathesis

Abstract: A stereoselective and convergent formal approach to Salicylihalamide A and B is achieved through our recently developed strategy for the construction of polyketide precursors via Prins cyclisation. The approach mainly relies upon reductive opening of 1-iodomethyl cyclic ethers, Mitsunobu inversion and ring closing metathesis along with Prins cyclisation.

Export Options

Export File:

RIS (for EndNote, Reference Manager, ProCite)

BibTeX

Text

Content:

Citation Only

Citation and Abstract

About this article

Cite this article as:

Yadav J.S., Venkateswar Rao N., Purushothama Rao P., Sridhar Reddy M. and Prasad A.R., Stereoselective Formal Synthesis of (-)-Salicylihalamides A and B Via Prins Cyclisation, Letters in Organic Chemistry 2010; 7 (6) . https://dx.doi.org/10.2174/157017810791824856