A Mild and Convenient Semi-Synthesis of Docetaxel from 10-Deacetyl Baccatin III

Title: A Mild and Convenient Semi-Synthesis of Docetaxel from 10-Deacetyl Baccatin III

Volume: 7 Issue: 6

Author(s): Hui Zhou, Dahai Chen, Hongwei Gao and Qingeng Li

Affiliation:

Keywords: Docetaxel, semi-synthesis, 10-DAB III, benzyl chloromate

Abstract: A novel protocol for the semi-synthesis of docetaxel was achieved in four steps from 10-deacetyl baccatin III with an overall yield of 50%. The key step is the selective protection of the C(7) and C(10) hydroxyl groups of 10- deacetyl baccatin III, utilizing benzyl chloromate as a selective protecting reagent, which are capable of being conveniently removed by Pd/C under hydrogen atmosphere.

Cite this article as:

Zhou Hui, Chen Dahai, Gao Hongwei and Li Qingeng, A Mild and Convenient Semi-Synthesis of Docetaxel from 10-Deacetyl Baccatin III, Letters in Organic Chemistry 2010; 7 (6) . https://dx.doi.org/10.2174/157017810791824892