Abstract
This review describes ylide 1,3-dipoles in cycloaddition reactions for the synthesis (and formal synthesis) of natural products. Examples using azomethine ylides, carbonyl ylides, nitrones, nitronates, nitrile oxides and azides are provided. These lead to a diverse array of heterocyclic products. Intramolecular cycloaddition provides two new rings in one step and hence an efficient entry to complex target compounds.
Keywords: Cycloaddition, dipoles, natural products, synthesis, ylides
Current Organic Synthesis
Title: Synthesis of Natural Products Using Intramolecular Dipolar Cycloaddition Reactions
Volume: 7 Issue: 4
Author(s): Adam J.M. Burrell and Iain Coldham
Affiliation:
Keywords: Cycloaddition, dipoles, natural products, synthesis, ylides
Abstract: This review describes ylide 1,3-dipoles in cycloaddition reactions for the synthesis (and formal synthesis) of natural products. Examples using azomethine ylides, carbonyl ylides, nitrones, nitronates, nitrile oxides and azides are provided. These lead to a diverse array of heterocyclic products. Intramolecular cycloaddition provides two new rings in one step and hence an efficient entry to complex target compounds.
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Cite this article as:
J.M. Burrell Adam and Coldham Iain, Synthesis of Natural Products Using Intramolecular Dipolar Cycloaddition Reactions, Current Organic Synthesis 2010; 7 (4) . https://dx.doi.org/10.2174/157017910791414472
DOI https://dx.doi.org/10.2174/157017910791414472 |
Print ISSN 1570-1794 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6271 |
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