Asymmetric Michael Addition of Aromatic Ketones to Nitroolefins Catalyzed by Simple Chiral Bifunctional Primary Amine-Thioureas

Title: Asymmetric Michael Addition of Aromatic Ketones to Nitroolefins Catalyzed by Simple Chiral Bifunctional Primary Amine-Thioureas

Volume: 7 Issue: 5

Author(s): Liangliang Wang, Xiaoying Xu, Jun Huang, Lin Peng, Qingchun Huang and Lixin Wang

Affiliation:

Keywords: Organocatalyst, Michael addition, aromatic ketones, nitroolefins, primary-amine thiourea

Abstract: Simple chiral primary amine-thiourea catalysts derived from chiral 1,2-diphenylethylenediamine were found to catalyze direct Michael addition of aromatic ketones to nitroolefins with good enantioselectives (up to 86% ee) and excellent yields (up to 97%) for a broad range of substrates and successfully used in the preparation of (R)-Balcofen.

Cite this article as:

Wang Liangliang, Xu Xiaoying, Huang Jun, Peng Lin, Huang Qingchun and Wang Lixin, Asymmetric Michael Addition of Aromatic Ketones to Nitroolefins Catalyzed by Simple Chiral Bifunctional Primary Amine-Thioureas, Letters in Organic Chemistry 2010; 7 (5) . https://dx.doi.org/10.2174/157017810791514652