The Two Pathways for Effective Orthogonal Protection of L-Ornithine, for Amino Acylation of 5-O-Pivaloyl Nucleosides, Describe the General and Important Role for the Successful Imitation, During the Synthesis of the Model Substrates for the Ribosomal Mimic Reaction

Title: The Two Pathways for Effective Orthogonal Protection of L-Ornithine, for Amino Acylation of 5-O-Pivaloyl Nucleosides, Describe the General and Important Role for the Successful Imitation, During the Synthesis of the Model Substrates for the Ribosomal Mimic Reaction

Volume: 17 Issue: 7

Author(s): Stanislav G. Bayryamov, Nikolay G. Vassilev and Dimiter D. Petkov

Affiliation:

Keywords: Conventional peptide synthesis, orthogonal protection, ornithine

Abstract: Bz(NO2)-Orn(Boc)-OCH2CN was synthesized as an amino acid component with effective and successful orthogonal protection for amino acylation of 5-O-Pivaloyl nucleosides and preparation of substrates for model ribosome reactions. The synthesis was carried out using suitable combinations of the methods of peptide synthesis and modification of amino acids.

Cite this article as:

G. Bayryamov Stanislav, G. Vassilev Nikolay and D. Petkov Dimiter, The Two Pathways for Effective Orthogonal Protection of L-Ornithine, for Amino Acylation of 5-O-Pivaloyl Nucleosides, Describe the General and Important Role for the Successful Imitation, During the Synthesis of the Model Substrates for the Ribosomal Mimic Reaction, Protein & Peptide Letters 2010; 17 (7) . https://dx.doi.org/10.2174/092986610791306625