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Mini-Reviews in Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

Polycationic Nanoparticles as Nonviral Vectors Employed for Gene Therapy in vivo

Author(s): Jinfeng Xing, Liandong Deng, Shutao Guo, Anjie Dong and Xing-Jie Liang

Volume 10, Issue 2, 2010

Page: [126 - 137] Pages: 12

DOI: 10.2174/138955710791185127

Price: $65

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Abstract

Currently, polycationic nanoparticles (polycation) as nonviral vectors are promising to overcome the defects of traditional viral vectors. This review focuses on the recent progress and challenges to improve the transfection efficacy and circulation time of polyplexes (complexes between polycation and pDNA or oligonucleotides such as siRNA ) in vivo.

Keywords: Gene therapy, polycation, nanoparticles, non-viral vectors, transfection efficiency, PEGylation, gene delivery, circulation time


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