Synthesis Optimization of Hydroxymethylnitrofurazone, an Antichagasic Candidate, Using 32 Factorial Design

Title: Synthesis Optimization of Hydroxymethylnitrofurazone, an Antichagasic Candidate, Using 32 Factorial Design

Volume: 7 Issue: 3

Author(s): Gustavo H.G. Trossini, Jeanine Giarolla, Leandro de Rezende, Antonia T. do Amaral, Marcio H. Zaim, Roy E. Bruns and Elizabeth I. Ferreira

Affiliation:

Keywords: Factorial design, synthesis optimization, hydroxymethylnitrofurazone (NFOH), antichagasic candidate, response surface methodology

Abstract: Hydroxymethylnitrofurazone presents in vitro activity against Trypanosoma cruzi. The optimization of the synthesis of this compound was performed through a 32 factorial statistical design. Quadratic model produced the best response surface predicting a maximum yield (82%) close to the center design point with a seven hours reaction and a 1:1.5 (NF:K2CO3) ratio.

Cite this article as:

H.G. Trossini Gustavo, Giarolla Jeanine, de Rezende Leandro, T. do Amaral Antonia, H. Zaim Marcio, E. Bruns Roy and I. Ferreira Elizabeth, Synthesis Optimization of Hydroxymethylnitrofurazone, an Antichagasic Candidate, Using 32 Factorial Design, Letters in Organic Chemistry 2010; 7 (3) . https://dx.doi.org/10.2174/157017810791112513