Gastrin: An Acid-Releasing, Proliferative and Immunomodulatory Peptide?

Title: Gastrin: An Acid-Releasing, Proliferative and Immunomodulatory Peptide?

Volume: 10 Issue: 1

Author(s): Sara Calatayud, Angeles Alvarez and Victor M. Victor

Affiliation:

Keywords: Gastrin, inflammation, immunomodulation, CCK-2 receptors, CCK-2 receptor antagonists

Abstract: Gastrin release is affected by gastric inflammatory conditions. Antral G cells respond to inflammatory mediators by increasing gastrin secretion. Accumulating experimental evidence suggests that gastrin exerts immunomodulatory and proinflammatory effects. Gastrin could be a contributing factor to these pathologies, which may constitute a new justification for pharmacological blockade of gastrin action.

Cite this article as:

Calatayud Sara, Alvarez Angeles and M. Victor Victor, Gastrin: An Acid-Releasing, Proliferative and Immunomodulatory Peptide?, Mini-Reviews in Medicinal Chemistry 2010; 10 (1) . https://dx.doi.org/10.2174/138955710791112532