Abstract
Flavonoids belong to polyphenolic secondary metabolites with broad-spectrum pharmacological activities and extensive biological effects, and the most prominent activity is their potential role as anticancer agents. In recent years, flavonoids and their synthetic analogues have been intensely investigated in the treatment of ovarian, breast, cervical, pancreatic, and prostate cancer. To some extent, chemical structures of flavonoids will influence their anticancer activities. Thus, some new analogues based on the structural skeleton of these flavonoids have been synthesized and investigated. This review presents recent advances on the patents concerning of the natural flavonoids and their synthetic analogues in the treatment of cancers, and new synthetic approaches and possible structure-activity relationships of flavonoids are also briefly summarized.
Keywords: Anticancer, flavonoids, synthetic analogue, flavones, isoflavone, flavonol, flavanol, anthocyanin, chalcone
Recent Patents on Anti-Cancer Drug Discovery
Title: Flavonoids: Recent Advances as Anticancer Drugs
Volume: 5 Issue: 2
Author(s): Hai L. Liu, Wen B. Jiang and Meng X. Xie
Affiliation:
Keywords: Anticancer, flavonoids, synthetic analogue, flavones, isoflavone, flavonol, flavanol, anthocyanin, chalcone
Abstract: Flavonoids belong to polyphenolic secondary metabolites with broad-spectrum pharmacological activities and extensive biological effects, and the most prominent activity is their potential role as anticancer agents. In recent years, flavonoids and their synthetic analogues have been intensely investigated in the treatment of ovarian, breast, cervical, pancreatic, and prostate cancer. To some extent, chemical structures of flavonoids will influence their anticancer activities. Thus, some new analogues based on the structural skeleton of these flavonoids have been synthesized and investigated. This review presents recent advances on the patents concerning of the natural flavonoids and their synthetic analogues in the treatment of cancers, and new synthetic approaches and possible structure-activity relationships of flavonoids are also briefly summarized.
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Cite this article as:
Liu L. Hai, Jiang B. Wen and Xie X. Meng, Flavonoids: Recent Advances as Anticancer Drugs, Recent Patents on Anti-Cancer Drug Discovery 2010; 5 (2) . https://dx.doi.org/10.2174/157489210790936261
DOI https://dx.doi.org/10.2174/157489210790936261 |
Print ISSN 1574-8928 |
Publisher Name Bentham Science Publisher |
Online ISSN 2212-3970 |
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