(Masked)serinols: Molecules, Biomolecules, Building-Blocks, Supramolecules.Part (I): Syntheses Based on Serinols Reactivity with Carbonyl Electrophiles

Mircea      Darabantu

doi:10.2174/157017910790820300

Abstract

Since the period of the 1940s, 2-aminopropane-1,3-diol (“serinol”) and its commercial C-substituted analogous are a popular motif in organic compounds covering almost all facets of organic synthesis. This first part of the review deals mainly with the nowadays approaches focused on serinolsreactivity with carbonyl electrophiles (aldehydes and ketones) as well as its applications.

Keywords: 2-aminopropane-1,3-diols, ring-chain tautomerism, 1,3-oxazolidines, 3,7-dioxa-1-azabicyclo[3.3.0]octanes, 5-amino-1,3-dioxanes, asymmetric synthesis

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Current Organic Synthesis

Title: (Masked)serinols: Molecules, Biomolecules, Building-Blocks, Supramolecules.Part (I): Syntheses Based on Serinols Reactivity with Carbonyl Electrophiles

Volume: 7 Issue: 2

Author(s): Mircea Darabantu

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Keywords: 2-aminopropane-1,3-diols, ring-chain tautomerism, 1,3-oxazolidines, 3,7-dioxa-1-azabicyclo[3.3.0]octanes, 5-amino-1,3-dioxanes, asymmetric synthesis

Abstract: Since the period of the 1940s, 2-aminopropane-1,3-diol (“serinol”) and its commercial C-substituted analogous are a popular motif in organic compounds covering almost all facets of organic synthesis. This first part of the review deals mainly with the nowadays approaches focused on serinolsreactivity with carbonyl electrophiles (aldehydes and ketones) as well as its applications.

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Darabantu Mircea, (Masked)serinols: Molecules, Biomolecules, Building-Blocks, Supramolecules.Part (I): Syntheses Based on Serinols Reactivity with Carbonyl Electrophiles, Current Organic Synthesis 2010; 7 (2) . https://dx.doi.org/10.2174/157017910790820300