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Letters in Organic Chemistry

Editor-in-Chief

ISSN (Print): 1570-1786
ISSN (Online): 1875-6255

Esterification of Unprotected α-Amino Acids in Ionic Liquids as the Reaction Media

Author(s): Daniele Biondini, Lucia Brinchi, Raimondo Germani, Laura Goracci and Gianfranco Savelli

Volume 7, Issue 1, 2010

Page: [39 - 44] Pages: 6

DOI: 10.2174/157017810790533940

Price: $65

Abstract

Ionic liquid 1,3-dimethylimidazolium methanesulfonate was used to prepare α-amino acids benzylic esters from unprotected amino acids and benzyl chloride. Esterification of several amino acids was achieved with satisfactory yields: by-products can be removed by a simple work-up procedure to afford the pure product. The described method is simple, mild, rapid and save.

Keywords: Ionic liquid, esterification, amino acids, nucleophilic substitution


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