Abstract
Peripheral benzodiazepine receptor (PBR) is an important target for the development of drugs to treat anxiety and sleep disorders. Hologram QSAR models were built for good statistical results. Contribution map analysis explains the individual atomic contributions to the overall activity. This HQSAR model should be useful for the further development of novel structurally related PBR ligands.
Keywords: Peripheral benzodiazepine receptor, Hologram QSAR
Letters in Drug Design & Discovery
Title: Hologram QSAR Studies of N,N-Dialkyl-2-phenylindol-3-ylglyoxylamides Derivatives as Selective Peripheral Benzodiazepine Receptor Ligands
Volume: 7 Issue: 2
Author(s): M. Ye
Affiliation:
Keywords: Peripheral benzodiazepine receptor, Hologram QSAR
Abstract: Peripheral benzodiazepine receptor (PBR) is an important target for the development of drugs to treat anxiety and sleep disorders. Hologram QSAR models were built for good statistical results. Contribution map analysis explains the individual atomic contributions to the overall activity. This HQSAR model should be useful for the further development of novel structurally related PBR ligands.
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Ye M., Hologram QSAR Studies of N,N-Dialkyl-2-phenylindol-3-ylglyoxylamides Derivatives as Selective Peripheral Benzodiazepine Receptor Ligands, Letters in Drug Design & Discovery 2010; 7 (2) . https://dx.doi.org/10.2174/157018010790225886
DOI https://dx.doi.org/10.2174/157018010790225886 |
Print ISSN 1570-1808 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-628X |
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