Abstract
Protein NMR as a screening tool in drug discovery has become prominent within the past ten years. Advances in protein manipulation, whether by biological means (labeling) or physical means (NMR), have created a powerful method that is able to observe ligand-target interactions in solution.
Keywords: NMR, Protein labeling, Chemical Shift Perturbtation, RAMPED-UP
Current Pharmaceutical Design
Title: Protein NMR-Based Screening in Drug Discovery
Volume: 12 Issue: 31
Author(s): E. R. Zartler and M. J. Shapiro
Affiliation:
Keywords: NMR, Protein labeling, Chemical Shift Perturbtation, RAMPED-UP
Abstract: Protein NMR as a screening tool in drug discovery has become prominent within the past ten years. Advances in protein manipulation, whether by biological means (labeling) or physical means (NMR), have created a powerful method that is able to observe ligand-target interactions in solution.
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Cite this article as:
Zartler R. E. and Shapiro J. M., Protein NMR-Based Screening in Drug Discovery, Current Pharmaceutical Design 2006; 12 (31) . https://dx.doi.org/10.2174/138161206778743619
DOI https://dx.doi.org/10.2174/138161206778743619 |
Print ISSN 1381-6128 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4286 |
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