A Convenient One Pot Synthesis of 3-Cyano-9-methyl-2-methylthio-4-oxo- 4H- pyrimido[2,1-b] pyrimido [4,5-b] Quinoline and its Reactions with Selected Nucleophiles

Title: A Convenient One Pot Synthesis of 3-Cyano-9-methyl-2-methylthio-4-oxo- 4H- pyrimido[2,1-b] pyrimido [4,5-b] Quinoline and its Reactions with Selected Nucleophiles

Volume: 6 Issue: 7

Author(s): Sambhaji P. Vartale, Vijay N. Bhosale, Sandeep V. Khansole and Ramdas N. Katapalle

Affiliation:

Keywords: One pot synthesis, pyrimido quinoline, ketene dithioacetals, N,N-dimethyl formamide, ring anellation, pyrimidine ring

Abstract: 3-Amino-8-methyl pyrimido [4,5-b] quinoline (1) in N,N-dimethyl formamide (DMF) and anhydrous potassium carbonate reacted with ethyl-2-cyano-3,3-bismethyl thioacrylate 2 to afford novel heterocyclic compound 3- cyano-9-methyl-2-methylthio-4-oxo-4H-pyrimido [4,5-b] quinoline 3. The latter were further reacted with selected N-, Oand C- nucleophiles such as arylamines, substituted phenols, heterylamines and compounds with an active methylene group.

Cite this article as:

Vartale P. Sambhaji, Bhosale N. Vijay, Khansole V. Sandeep and Katapalle N. Ramdas, A Convenient One Pot Synthesis of 3-Cyano-9-methyl-2-methylthio-4-oxo- 4H- pyrimido[2,1-b] pyrimido [4,5-b] Quinoline and its Reactions with Selected Nucleophiles, Letters in Organic Chemistry 2009; 6 (7) . https://dx.doi.org/10.2174/157017809789869537