Synthesis of a Novel Heterocyclic System - Pyrimido[5,4:5,6]thiopyrano [2,3-b]indole

Title: Synthesis of a Novel Heterocyclic System - Pyrimido[5,4:5,6]thiopyrano [2,3-b]indole

Volume: 6 Issue: 7

Author(s): Jurgis Sudzius and Sigitas Tumkevicius

Affiliation:

Keywords: indoline-2-thione, pyrimidine-5-carbaldehydes, cyclocondensation, nucleophilic substitution, pyrimido[5',4':5,6] thiopyrano[2,3-b]indoles

Abstract: An efficient protocol for the synthesis of pyrimido[5,4p:5,6]thiopyrano[2,3-b]indoles by the cyclocondensation of 1,3-dihydro-2H-indole-2-thione with 6-chloropyrimidine-5-carbaldehydes has been developed. 4-Chloro-2- methylthiopyrimido[5,4:5,6]thiopyrano[2,3-b]indole was found to undergo smooth nucleophilic substitution with various nucleophiles to give 4-substituted pyrimido[5,4:5,6]thiopyrano[2,3-b]indoles.

Cite this article as:

Sudzius Jurgis and Tumkevicius Sigitas, Synthesis of a Novel Heterocyclic System - Pyrimido[5,4:5,6]thiopyrano [2,3-b]indole, Letters in Organic Chemistry 2009; 6 (7) . https://dx.doi.org/10.2174/157017809789869492