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Letters in Drug Design & Discovery

Editor-in-Chief

ISSN (Print): 1570-1808
ISSN (Online): 1875-628X

Design, Synthesis, and Biological Evaluation of 7H-thiazolo[3,2-b]-1,2,4-triazin-7-one Derivatives as Acetylcholinesterase Inhibitors

Author(s): Si-Jie Liu, Liu Yang, Xiao-Guang Liu, Ying Luo, Zi-Jian Cao, David Chi Cheong Wan, Huang-Quan Lin and Chun Hu

Volume 7, Issue 1, 2010

Page: [5 - 8] Pages: 4

DOI: 10.2174/157018010789869343

Price: $65

Abstract

The docking study on a series of 7H-thiazolo[3,2-b]-1,2,4-triazin-7-one derivatives with acetylcholinesterase has been demonstrated. The synthesis and characterization of a series of 7H-thiazolo[3,2-b]-1,2,4-triazin-7-one derivatives were described. All target compounds were evaluated in vitro for the inhibitory activities against AChE via Ellman colorimetric assay. Most of the target compounds possessed anti-acetylcholinesterase activity. The preliminary structure-activity relationships were discussed.

Keywords: Acetylcholinesterase, Inhibitors, Synthesis, Heterocycles, Docking, 7H-thiazolo[3,2-b]-1,2,4-triazin-7-one derivative


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