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Protein & Peptide Letters

Editor-in-Chief

ISSN (Print): 0929-8665
ISSN (Online): 1875-5305

Novel Antimicrobial Peptides Isolated from Skin Secretions of the Mexican Frog Hyla eximia

Author(s): Oscar Villa-Hernandez, Lorena Hernandez-Orihuela, Maria del Carmen Rodriguez, Fernando Zamudio-Zuniga, Ruben Castro-Franco, Victoria Pando and Cesar V.F. Batista

Volume 16, Issue 11, 2009

Page: [1371 - 1378] Pages: 8

DOI: 10.2174/092986609789353727

Price: $65

Abstract

In this work, we describe the original characterization of peptides and proteins present in the skin secretions of the Mexican amphibian Hyla eximia. To this purpose, a novel water/dark extraction method, as well as the classic electrical stimulation procedure, was applied in order to extract the skin secretion. Two novel antimicrobial peptides He-1 and He-2 were sequenced. In addition, a molecular mass fingerprint revealed more than one hundred different molecules. Eight peptides in homogeneous form were assayed against five species of bacteria. Thereafter, the peptide He-2 demonstrated high antiparasitic activity against ookinete forms of malaria parasites at low concentration.

Keywords: Hyla eximia, antimicrobial peptides, mass spectrometry


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