Synthesis and Characterization of Substituted Ethyl 2-(1-aminocyclobutyl)- 5-(benzoyloxy)-6-hydroxypyrimidine-4-carboxylate Derivatives as Antioxidant Agents

Title: Synthesis and Characterization of Substituted Ethyl 2-(1-aminocyclobutyl)- 5-(benzoyloxy)-6-hydroxypyrimidine-4-carboxylate Derivatives as Antioxidant Agents

Volume: 6 Issue: 8

Author(s): D. Asha, Manish Malviya, S. Chandrappa, C. T. Sadashiva, K. Vinaya, D. S. Prasanna and K. S. Rangappa

Affiliation:

Keywords: Benzyl 1-cyanocyclobutylcarbamate, Pyrimidine, Hydroxy radical, DPPH Assay, Antioxidant

Abstract: A series of novel ethyl 2-(1-aminocyclobutyl)-5-(benzoyloxy)-6-hydroxy-pyrimidine-4-carboxylate derivatives 8(a-i) were synthesized by nucleophilic substitution reaction of ethyl 2-(1-aminocyclobutyl)-5-(benzoyloxy)-6-hydroxypyrimidine- 4-carboxylate (7) with different substituted aliphatic/aromatic sulfonyl chlorides (R-SO2-Cl). All the synthesized compounds were characterized by IR, 1H NMR and LC/MS analysis. The synthesized compounds were evaluated for their antioxidant activity by diphenylpicrylhydrazyl (DPPH) assay and also by hydroxy radical induced DNA strand scission assay. Among the synthesized compounds 8c, 8f and 8i showed promising antioxidant activity.

Cite this article as:

Asha D., Malviya Manish, Chandrappa S., Sadashiva T. C., Vinaya K., Prasanna S. D. and Rangappa S. K., Synthesis and Characterization of Substituted Ethyl 2-(1-aminocyclobutyl)- 5-(benzoyloxy)-6-hydroxypyrimidine-4-carboxylate Derivatives as Antioxidant Agents, Letters in Drug Design & Discovery 2009; 6 (8) . https://dx.doi.org/10.2174/157018009789353509

DOI https://dx.doi.org/10.2174/157018009789353509	Print ISSN 1570-1808
Publisher Name Bentham Science Publisher	Online ISSN 1875-628X