Design and Synthesis of Pterin Derivares as Nitric Oxide Synthase Inhibitors

Title: Design and Synthesis of Pterin Derivares as Nitric Oxide Synthase Inhibitors

Volume: 6 Issue: 8

Author(s): Fei Ma, Ping Guo, Lixun Jiang, Mingsheng Feng, Jingbo Shi and Qizheng Yao

Affiliation:

Keywords: Pterin, Tetrahydrobiopterin, Synthesis, Nitric oxide synthase, Inhibitive activity, In vitro

Abstract: In this paper, we reported the design, and synthesis of a series of novel pterin derivates i.e. 8a∼f, 9a∼f and 10a∼d. Their inhibitory activity against inducible nitric oxide synthase (iNOS) was evaluated in vitro. It was demonstrated that 4-alkoxypterin derivatives with acylation of 2-amino group showed potent inhibitory activity against iNOS, especially 8c, 8f and 10c.

Cite this article as:

Ma Fei, Guo Ping, Jiang Lixun, Feng Mingsheng, Shi Jingbo and Yao Qizheng, Design and Synthesis of Pterin Derivares as Nitric Oxide Synthase Inhibitors, Letters in Drug Design & Discovery 2009; 6 (8) . https://dx.doi.org/10.2174/157018009789353482