Selective Synthesis of Unsaturated N-Acylethanolamines by Lipase- Catalyzed N-Acylation of Ethanolamine with Unsaturated Fatty Acids

Title: Selective Synthesis of Unsaturated N-Acylethanolamines by Lipase- Catalyzed N-Acylation of Ethanolamine with Unsaturated Fatty Acids

Volume: 6 Issue: 6

Author(s): Pierluigi Plastina, Jocelijn Meijerink, Jean-Paul Vincken, Harry Gruppen, Renger Witkamp and Bartolo Gabriele

Affiliation:

Keywords: Acylation, enzymatic catalysis, lipase, unsaturated N-acylethanolamines, unsaturated fatty acids

Abstract: The selective synthesis of unsaturated N-acylethanolamines 1b-6b by lipase-catalyzed direct condensation between unsaturated fatty acids 1a-6a and ethanolamine is reported. Reactions were carried out in hexane at 40 °C, in the presence of Candida antarctica Lipase B as the catalyst, to give the corresponding amides 1b-6b with yields ranging from 80 to 88%.

Cite this article as:

Plastina Pierluigi, Meijerink Jocelijn, Vincken Jean-Paul, Gruppen Harry, Witkamp Renger and Gabriele Bartolo, Selective Synthesis of Unsaturated N-Acylethanolamines by Lipase- Catalyzed N-Acylation of Ethanolamine with Unsaturated Fatty Acids, Letters in Organic Chemistry 2009; 6 (6) . https://dx.doi.org/10.2174/157017809789124885