Total Synthesis and Analgesic Activity of 6-Fluoroindan-1-acetic Acid and its 3-Oxo Derivative

Title: Total Synthesis and Analgesic Activity of 6-Fluoroindan-1-acetic Acid and its 3-Oxo Derivative

Volume: 5 Issue: 5

Author(s): Hasina Yasmin, Sharmistha Das, Lutfun Nahar, M. Mehedi Masud, M. Shafikur Rahman, Suvash C. Roy, M. Mukhlesur Rahman, Simon Gibbons, Joydeb K. Kundu, Bidyut K. Datta, Sitesh C. Bachar, A. K. Azad Chowdhury and Satyajit D. Sarker

Affiliation:

Keywords: 3-fluorobenzylidine-bis-acetoacetate, 3-fluoro-β-phenyl glutaric acid, 6-fluoro-3-oxo-indan-1-acetic acid, 6-fluoroindan-1-acetic acid, analgesic activity

Abstract: 6-Fluoro-3-oxo-indan-1-acetic acid (5) and 6-fluoroindan-1-acetic acid (6) were conveniently synthesised from 3-fluorobenzaldehyde in four and five steps, respectively. The structures of these new compounds and two other intermediates, 3-fluorobenzylidine-bis-acetoacetate (2) and 3-fluoro-β-phenyl glutaric acid (3) were elucidated by spectroscopic means, notably, HRMS, 1D and 2D NMR. The analgesic activity of compounds 5 and 6 were assessed by the acetic acid induced writhing in Swiss albino mice.

Cite this article as:

Yasmin Hasina, Das Sharmistha, Nahar Lutfun, Masud Mehedi M., Rahman Shafikur M., Roy C. Suvash, Rahman Mukhlesur M., Gibbons Simon, Kundu K. Joydeb, Datta K. Bidyut, Bachar C. Sitesh, Azad Chowdhury K. A. and Sarker D. Satyajit, Total Synthesis and Analgesic Activity of 6-Fluoroindan-1-acetic Acid and its 3-Oxo Derivative, Medicinal Chemistry 2009; 5 (5) . https://dx.doi.org/10.2174/157340609789117831