Abstract
Carbohydrate-protein interactions play a major-role in recognition of cells by external macromolecules. Single saccharide ligands, however, bind only weakly to their protein receptors. Sufficient affinity is achieved by appropriate mutual orientation of the saccharide epitopes and their protein receptors, which allows multiple simultaneous interactions. Solid-supported methods allowing synthesis of multiantennary glycoconjugates have, hence, been under active development. The present paper is a review of the solid-phase protocols useful for preparation of glycoconjugates.
Related Books
Advances in Organic Synthesis
The Synthetic Methods, Structures, and Properties of the Ca-C σ Bond Organocalcium Containing Compounds
Advances in Organic Synthesis
Chemistry of Bipyrazoles: Synthesis and Applications
Advances in Organic Synthesis
Advanced Nanocatalysis for Organic Synthesis and Electroanalysis
Advances in Organic Synthesis
Advances in Organic Synthesis
2