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Current Organic Synthesis

Editor-in-Chief

ISSN (Print): 1570-1794
ISSN (Online): 1875-6271

Biocatalysis in the Preparation of the Statin Side Chain

Author(s): Arto Liljeblad, Annukka Kallinen and Liisa T. Kanerva

Volume 6, Issue 4, 2009

Page: [362 - 379] Pages: 18

DOI: 10.2174/157017909789108738

Price: $65

Abstract

Statins used in the treatment of dyslipidemias are top-selling drugs in the world. Economical production of statins in industrial scale is challenging, because the side chain of statins is a 3,5-dihydroxyacid derivative consisting of two asymmetric centers. The most prominent methods for the preparation of the side chain are based on biocatalysis and surveyed in this review.

Keywords: Statin, cardiovascular disease, biocatalysis, dehydrogenase, lipase, haloalcohol dehalogenase, nitrilase, aldolase


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