Abstract
Statins used in the treatment of dyslipidemias are top-selling drugs in the world. Economical production of statins in industrial scale is challenging, because the side chain of statins is a 3,5-dihydroxyacid derivative consisting of two asymmetric centers. The most prominent methods for the preparation of the side chain are based on biocatalysis and surveyed in this review.
Keywords: Statin, cardiovascular disease, biocatalysis, dehydrogenase, lipase, haloalcohol dehalogenase, nitrilase, aldolase
Current Organic Synthesis
Title: Biocatalysis in the Preparation of the Statin Side Chain
Volume: 6 Issue: 4
Author(s): Arto Liljeblad, Annukka Kallinen and Liisa T. Kanerva
Affiliation:
Keywords: Statin, cardiovascular disease, biocatalysis, dehydrogenase, lipase, haloalcohol dehalogenase, nitrilase, aldolase
Abstract: Statins used in the treatment of dyslipidemias are top-selling drugs in the world. Economical production of statins in industrial scale is challenging, because the side chain of statins is a 3,5-dihydroxyacid derivative consisting of two asymmetric centers. The most prominent methods for the preparation of the side chain are based on biocatalysis and surveyed in this review.
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Cite this article as:
Liljeblad Arto, Kallinen Annukka and Kanerva T. Liisa, Biocatalysis in the Preparation of the Statin Side Chain, Current Organic Synthesis 2009; 6 (4) . https://dx.doi.org/10.2174/157017909789108738
DOI https://dx.doi.org/10.2174/157017909789108738 |
Print ISSN 1570-1794 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6271 |
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