Synthesis of Organic Carbamates without Using Phosgene: Carbonylation of Amines with Carbonic Acid Diesters

M.      Carafa; E.      Quaranta

doi:10.2174/157019309788922720

Abstract

Aminolysis of organic carbonates is a suitable phosgene-free synthetic route to carbamate esters. The paper reviews recent advances in this field. Emphasis is laid on the reaction of amines with industrially relevant carbonic acid diesters, (MeO)2CO, (PhO)2CO, MeOC(O)OPh, currently obtainable without using phosgene. The carbonylation process may require a catalyst. The use of effective catalytic systems is highlighted and their mode of action is discussed.

Keywords: Carbamates, organic carbonates, phosgene substitution, carbonylation, catalysis

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Mini-Reviews in Organic Chemistry

Title: Synthesis of Organic Carbamates without Using Phosgene: Carbonylation of Amines with Carbonic Acid Diesters

Volume: 6 Issue: 3

Author(s): M. Carafa and E. Quaranta

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Keywords: Carbamates, organic carbonates, phosgene substitution, carbonylation, catalysis

Abstract: Aminolysis of organic carbonates is a suitable phosgene-free synthetic route to carbamate esters. The paper reviews recent advances in this field. Emphasis is laid on the reaction of amines with industrially relevant carbonic acid diesters, (MeO)2CO, (PhO)2CO, MeOC(O)OPh, currently obtainable without using phosgene. The carbonylation process may require a catalyst. The use of effective catalytic systems is highlighted and their mode of action is discussed.

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Carafa M. and Quaranta E., Synthesis of Organic Carbamates without Using Phosgene: Carbonylation of Amines with Carbonic Acid Diesters, Mini-Reviews in Organic Chemistry 2009; 6 (3) . https://dx.doi.org/10.2174/157019309788922720