Abstract
This review describes, briefly, the characteristics and regulation of glycogen synthase kinase 3 (GSK3) together with the role of GSK3 dysfunctions in different pathologies, and GSK3 as target for therapeutic treatment in different diseases. Several GSK3 inhibitors acting at different levels are described in this work, ranging from cations like lithium to small compounds developed by different pharmaceutical companies. Also, the use of specific interference RNA (iRNA) for the specific inhibition of the expression of the different GSK3 isoforms is discussed.
Keywords: GSK3, lithium, Alzheimer, neurodegeneration
Mini-Reviews in Medicinal Chemistry
Title: GSK3 Inhibitors and Disease
Volume: 9 Issue: 9
Author(s): Felix Hernandez, Javier Diaz Nido, Jesus Avila and Nieves Villanueva
Affiliation:
Keywords: GSK3, lithium, Alzheimer, neurodegeneration
Abstract: This review describes, briefly, the characteristics and regulation of glycogen synthase kinase 3 (GSK3) together with the role of GSK3 dysfunctions in different pathologies, and GSK3 as target for therapeutic treatment in different diseases. Several GSK3 inhibitors acting at different levels are described in this work, ranging from cations like lithium to small compounds developed by different pharmaceutical companies. Also, the use of specific interference RNA (iRNA) for the specific inhibition of the expression of the different GSK3 isoforms is discussed.
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Cite this article as:
Hernandez Felix, Nido Diaz Javier, Avila Jesus and Villanueva Nieves, GSK3 Inhibitors and Disease, Mini-Reviews in Medicinal Chemistry 2009; 9 (9) . https://dx.doi.org/10.2174/138955709788922647
DOI https://dx.doi.org/10.2174/138955709788922647 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
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