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Protein & Peptide Letters

Editor-in-Chief

ISSN (Print): 0929-8665
ISSN (Online): 1875-5305

Brown Recluse Spider Venom: Proteomic Analysis and Proposal of a Putative Mechanism of Action

Author(s): Lucilene D. dos Santos, Nathalia B. Dias, Jose Roberto, A. S. Pinto and Mario S. Palma

Volume 16, Issue 8, 2009

Page: [933 - 943] Pages: 11

DOI: 10.2174/092986609788923383

Price: $65

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Abstract

Loxosceles intermedia spider venom was subjected to proteomic analysis through a MudPIT shot-gun approach to identify the protein composition. Were identified 39 proteins which seem to responsible by the lesion of different types of tissues, to some physiopathological actions and by the prevention of structural damage to the toxin structures.

Keywords: Proteomic analysis, spider venom, MudPIT, mass spectrometry, mechanism of action


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