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Letters in Organic Chemistry

Editor-in-Chief

ISSN (Print): 1570-1786
ISSN (Online): 1875-6255

Asymmetric α-Amination of Aldehydes and Ketones Catalyzed by tert-Butoxy-L-Proline

Author(s): Ramzi Ait-Youcef, Delphine Kalch, Xavier Moreau, Christine Thomassigny and Christine Greck

Volume 6, Issue 5, 2009

Page: [377 - 380] Pages: 4

DOI: 10.2174/157017809788681293

Price: $65

Abstract

Asymmetric electrophilic α-amination of aldehydes and ketones is described using trans-3-tert-butoxy-Lproline and trans-4-tert-butoxy-L-proline as efficient catalysts. Good yields and high enantioselectivities are obtained working at 0°C or at room temperature with a catalyst loading of only 5 mol%.

Keywords: Electrophilic amination, organocatalysis, tert-butoxyproline, azodicarboxylate, α-hydrazinoalcohol


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