Bone-Targeting Anthraquinone-Diclofenac Prodrugs with Hydrolytic and Bone Affinity Characteristics

Title: Bone-Targeting Anthraquinone-Diclofenac Prodrugs with Hydrolytic and Bone Affinity Characteristics

Volume: 6 Issue: 5

Author(s): Yanbing Duan, Jia Yu, Haifeng Liu and Min Ji

Affiliation:

Keywords: Bone-targeting, Anthraquinone, Prodrug, Hydrolytic, Bone affinity, Anti-inflammatory

Abstract: Two hydrolytically activated anthraquinone-diclofenac prodrugs have been designed and synthesized. Both prodrugs show significant binding capability to hydroxyapative (HAP), the major component of bone, and hydrolytically activity in simulation physiological conditions in vitro.

Cite this article as:

Duan Yanbing, Yu Jia, Liu Haifeng and Ji Min, Bone-Targeting Anthraquinone-Diclofenac Prodrugs with Hydrolytic and Bone Affinity Characteristics, Letters in Drug Design & Discovery 2009; 6 (5) . https://dx.doi.org/10.2174/1570180810906050393

DOI https://dx.doi.org/10.2174/1570180810906050393	Print ISSN 1570-1808
Publisher Name Bentham Science Publisher	Online ISSN 1875-628X