Abstract
The mechanism by which herpesviruses fuse with cellular membranes to permit virus entry is still relatively poorly understood. This process is proving difficult to unravel, largely due to the fact that multiple viral envelope proteins appear to function in concert to mediate the fusion event. For Herpes Simplex Virus Type 1 (HSV1), glycoproteins B, D and the gHL heterodimer are all required for fusion, and gHL counterparts are involved in the fusion process of all other members of the herpesvirus family. An understanding of the functional domains of gH that are critical for fusion may offer the possibility of designing specific peptide inhibitors of virus entry, and recent progress has highlighted the potential usefulness of this approach. This review discusses these advances and outlines some of the similarities and differences between gH homologues of the different members of this diverse family of viruses.
Keywords: Herpesvirus, glycoprotein H, membrane fusion
Protein & Peptide Letters
Title: The Role of Glycoprotein H in Herpesvirus Membrane Fusion
Volume: 16 Issue: 7
Author(s): H. M. Browne
Affiliation:
Keywords: Herpesvirus, glycoprotein H, membrane fusion
Abstract: The mechanism by which herpesviruses fuse with cellular membranes to permit virus entry is still relatively poorly understood. This process is proving difficult to unravel, largely due to the fact that multiple viral envelope proteins appear to function in concert to mediate the fusion event. For Herpes Simplex Virus Type 1 (HSV1), glycoproteins B, D and the gHL heterodimer are all required for fusion, and gHL counterparts are involved in the fusion process of all other members of the herpesvirus family. An understanding of the functional domains of gH that are critical for fusion may offer the possibility of designing specific peptide inhibitors of virus entry, and recent progress has highlighted the potential usefulness of this approach. This review discusses these advances and outlines some of the similarities and differences between gH homologues of the different members of this diverse family of viruses.
Export Options
About this article
Cite this article as:
Browne M. H., The Role of Glycoprotein H in Herpesvirus Membrane Fusion, Protein & Peptide Letters 2009; 16 (7) . https://dx.doi.org/10.2174/092986609788681850
DOI https://dx.doi.org/10.2174/092986609788681850 |
Print ISSN 0929-8665 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5305 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
MicroRNAs-Based Therapeutic Strategy for Virally Induced Diseases
Current Drug Discovery Technologies Separation of Bioactive Metabolites from Aphanothece Halophytica Through HPLC and Characterization of the Analytes Through ESI-MS and NMR
The Natural Products Journal Targeting Heat Shock Proteins 70/90 and Proteasome for Cancer Therapy
Current Medicinal Chemistry Magnetite Nanostructures with Applications in Cancer Therapy
Current Proteomics Molecular and Cellular Activities of Vitamin E Analogues
Mini-Reviews in Medicinal Chemistry The Impact of Small Heat Shock Proteins (HspBs) in Alzheimer’s and Other Neurological Diseases
Current Pharmaceutical Design Clinical Studies with Targeted Toxins in Malignant Glioma
Reviews on Recent Clinical Trials Inhibitors of Lactate Dehydrogenase Isoforms and their Therapeutic Potentials
Current Medicinal Chemistry Detection of VEGF165 Using an Aptamer Affinity Probe in Microchip Capillary Electrophoresis
Current Pharmaceutical Analysis Interferon Treatment in Patients with Hypereosinophilia
Current Drug Targets An Update in the Development of HIV Entry Inhibitors
Current Topics in Medicinal Chemistry Perinatal Gene Transfer to the Liver
Current Pharmaceutical Design Dexrazoxane for the Prevention of Cardiac Toxicity and Treatment of Extravasation Injury from the Anthracycline Antibiotics
Current Pharmaceutical Biotechnology Adipose-Derived Stromal/Stem Cells (ASC) in Regenerative Medicine: Pharmaceutical Applications
Current Pharmaceutical Design Aryltetralin-type Lignan of Podophyllum: A Comprehensive Review
The Natural Products Journal Heat Shock Protein (HSP) Drug Discovery and Development: Targeting Heat Shock Proteins in Disease
Current Topics in Medicinal Chemistry Biological and Pharmacological Roles of N6-Isopentenyladenosine: An Emerging Anticancer Drug
Anti-Cancer Agents in Medicinal Chemistry Diterpenoids- Potential Chemopreventive and Chemotherapeutic Agents in Leukemia
Current Pharmaceutical Biotechnology Antiangiogenic Therapy
Current Pharmaceutical Design Structural and Functional Organization of miRNAs
Current Pharmacogenomics