Effects of Ionic Liquids for Lipase-Catalyzed Chiral 1,1-binaphthyl-2- yl(phenyl)methanone O-acetyl Oxime Synthesis

Title: Effects of Ionic Liquids for Lipase-Catalyzed Chiral 1,1-binaphthyl-2- yl(phenyl)methanone O-acetyl Oxime Synthesis

Volume: 6 Issue: 4

Author(s): Yongchang Zhou, Motohiro Takahashi, Naoto Aoyagi, Chunlei Li, Tatsuro Kijima and Taeko Izumi

Affiliation:

Keywords: Ionic liquids, Lipase-catalyzed, Chiral, O-acetyl oxime, Synthesis, Resolution

Abstract: The resolution of 1,1-binaphthyl-2-yl(phenyl)methanone O-acetyl oxime catalyzed by lipase in three different ionic liquids, 1-butyl-3-methylimidazolium hexafluoride-phosphate, [bmim][PF6], 1-butyl-3-methylimidazolium tetrafluoroborate, [bmim][BF4] and N-butyl-pyridium hexafluorophosphate, [BuPy][PF6] and organic solvents was studied. The lipase shows low activity in ionic liquids and organic solvent with ionic liquids as the additive, while the lipase coated with ionic liquids gives the best enantioselectivity as high as 95 %.

Cite this article as:

Zhou Yongchang, Takahashi Motohiro, Aoyagi Naoto, Li Chunlei, Kijima Tatsuro and Izumi Taeko, Effects of Ionic Liquids for Lipase-Catalyzed Chiral 1,1-binaphthyl-2- yl(phenyl)methanone O-acetyl Oxime Synthesis, Letters in Organic Chemistry 2009; 6 (4) . https://dx.doi.org/10.2174/157017809788489864