First Synthesis of Lissoclimide-Type Alkaloids

Miguel   A.   Gonzalez; Damaris      Romero; Bibiana      Zapata; Liliana      Betancur-Galvis

doi:10.2174/157017809788489828

Abstract

The first synthesis of lissoclimide-type alkaloids is described. Starting from commercial (+)-sclareolide, the aldehyde γ-bicyclohomofarnesal is synthesized and coupled, through an aldol reaction, with succinimide. The antitumor activity of several lissoclimide analogues is also reported.

Keywords: Lissoclimide, Haterumaimide, Diterpene, Alkaloid, Cytotoxicity, Aldol

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Letters in Organic Chemistry

Title: First Synthesis of Lissoclimide-Type Alkaloids

Volume: 6 Issue: 4

Author(s): Miguel A. Gonzalez, Damaris Romero, Bibiana Zapata and Liliana Betancur-Galvis

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Keywords: Lissoclimide, Haterumaimide, Diterpene, Alkaloid, Cytotoxicity, Aldol

Abstract: The first synthesis of lissoclimide-type alkaloids is described. Starting from commercial (+)-sclareolide, the aldehyde γ-bicyclohomofarnesal is synthesized and coupled, through an aldol reaction, with succinimide. The antitumor activity of several lissoclimide analogues is also reported.

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Gonzalez A. Miguel, Romero Damaris, Zapata Bibiana and Betancur-Galvis Liliana, First Synthesis of Lissoclimide-Type Alkaloids, Letters in Organic Chemistry 2009; 6 (4) . https://dx.doi.org/10.2174/157017809788489828