HIV Co-Receptor CCR5: Structure and Interactions with Inhibitors

Title: HIV Co-Receptor CCR5: Structure and Interactions with Inhibitors

Volume: 9 Issue: 3

Author(s): Ting Wang and Yong Duan

Affiliation:

Keywords: CC-chemokine Receptor 5 (CCR5), HIV entry inhibitors, homology modeling, G-protein coupled receptor (GPCR), molecular docking, drug design

Abstract: The CC-chemokine receptor 5 (CCR5), a membrane protein belonging to the G-protein coupled receptor superfamily, has been identified as an essential co-receptor for HIV entry into the cells, and small molecules that inhibit HIV entry by targeting CCR5 have been in fast development as antiviral agents. This review focuses on computational studies of predicting the CCR5 structure and its interactions with known small molecule inhibitors and discusses how the recently solved GPCR structures would provide new insights into the modeling of CCR5-inhibitior binding. In addition, this review pays a particular attention to the design of the inhibitors that specifically interrupt the viral entry co-receptor activity of CCR5 while preserving its normal chemokine receptor function to minimize side effects and toxicity.

Cite this article as:

Wang Ting and Duan Yong, HIV Co-Receptor CCR5: Structure and Interactions with Inhibitors, Infectious Disorders - Drug Targets 2009; 9 (3) . https://dx.doi.org/10.2174/1871526510909030279