Abstract
As the traditional in vivo tests are gradually shifting into in vitro tests, some new issues become apparent. This review discusses the essential considerations in endpoint selection, cell model quality, exposure concentration and linking factors between in vitro and in vivo studies in using in vitro models in risk assessment.
Mini-Reviews in Medicinal Chemistry
Title: Current Considerations for the Effective Safety Evaluation of Drugs In Vitro
Volume: 9 Issue: 7
Author(s): Jinsheng Xu and Simon K. Jackson
Affiliation:
Abstract: As the traditional in vivo tests are gradually shifting into in vitro tests, some new issues become apparent. This review discusses the essential considerations in endpoint selection, cell model quality, exposure concentration and linking factors between in vitro and in vivo studies in using in vitro models in risk assessment.
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Cite this article as:
Xu Jinsheng and Jackson K. Simon, Current Considerations for the Effective Safety Evaluation of Drugs In Vitro, Mini-Reviews in Medicinal Chemistry 2009; 9 (7) . https://dx.doi.org/10.2174/138955709788452577
DOI https://dx.doi.org/10.2174/138955709788452577 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
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