DNA Binders: 2. Molecular Recognition of DNA by 2,3,6,7-tetrahydro-1Hpyrrolo[1,2-a]indole-1,8(5H)-dione bis(4,5-dihydro-1H-imidazol-2-ylhydrazone) as a Prototype of “Two-Armed” Intercalating Agents

Title: DNA Binders: 2. Molecular Recognition of DNA by 2,3,6,7-tetrahydro-1Hpyrrolo[1,2-a]indole-1,8(5H)-dione bis(4,5-dihydro-1H-imidazol-2-ylhydrazone) as a Prototype of “Two-Armed” Intercalating Agents

Volume: 6 Issue: 4

Author(s): Roberto Dallocchio, Alessandro Dessi, Vanna Sanna, Nicolino Pala, Ilaria Campesi, Giuseppe Paglietti and Mario Sechi

Affiliation:

Keywords: DNA binders, Intercalation, Molecular dynamic, Relaxed complex method, Viscosimetry, Two-armed derivatives, 2,3,6,7-Tetrahydro-1H-pyrrolo[1,2-a]indole-1, 8(5H)-dione bis(4,5-dihydro-1H-imidazol-2-yl-hydrazone)

Abstract: The ability of the docking program AutoDock in studying the binding of small molecules to DNA is examined. Herein, we report molecular dynamic studies with the relaxed complex method applied to DNA, and viscosimetric titration results, performed to investigate a possible DNA-binding mode of a model compound of the previously reported “two armed” class of binders.

Cite this article as:

Dallocchio Roberto, Dessi Alessandro, Sanna Vanna, Pala Nicolino, Campesi Ilaria, Paglietti Giuseppe and Sechi Mario, DNA Binders: 2. Molecular Recognition of DNA by 2,3,6,7-tetrahydro-1Hpyrrolo[1,2-a]indole-1,8(5H)-dione bis(4,5-dihydro-1H-imidazol-2-ylhydrazone) as a Prototype of “Two-Armed” Intercalating Agents, Letters in Drug Design & Discovery 2009; 6 (4) . https://dx.doi.org/10.2174/157018009788452537

DOI https://dx.doi.org/10.2174/157018009788452537	Print ISSN 1570-1808
Publisher Name Bentham Science Publisher	Online ISSN 1875-628X