Abstract
The silencing of genes by RNA interference (RNAi) has identified proteins involved in the resistance of cancers to chemotherapeutic drugs. Resistance is associated with defects in the apoptotic signaling pathways. In this article, we examine using RNAi to target the anti-apoptotic protein cellular FLICE-like inhibitory protein (c-FLIP) for drug development.
Keywords: RNA interference, c-FLIP, apoptosis, apoptotic pathways, drug discovery, cancer, caspases
Mini-Reviews in Medicinal Chemistry
Title: RNA Interference in Cancer: Targeting the Anti-Apoptotic Protein c-FLIP for Drug Discovery
Volume: 9 Issue: 6
Author(s): Travis W. Day and Ahmad R. Safa
Affiliation:
Keywords: RNA interference, c-FLIP, apoptosis, apoptotic pathways, drug discovery, cancer, caspases
Abstract: The silencing of genes by RNA interference (RNAi) has identified proteins involved in the resistance of cancers to chemotherapeutic drugs. Resistance is associated with defects in the apoptotic signaling pathways. In this article, we examine using RNAi to target the anti-apoptotic protein cellular FLICE-like inhibitory protein (c-FLIP) for drug development.
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Cite this article as:
Day W. Travis and Safa R. Ahmad, RNA Interference in Cancer: Targeting the Anti-Apoptotic Protein c-FLIP for Drug Discovery, Mini-Reviews in Medicinal Chemistry 2009; 9 (6) . https://dx.doi.org/10.2174/138955709788452748
DOI https://dx.doi.org/10.2174/138955709788452748 |
Print ISSN 1389-5575 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5607 |
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