Abstract
The voltage-gated sodium channels are a family of proteins that control the flow of sodium ions across cell membranes. Considerable data support the hypothesis that hyperexcitability and spontaneous action potential firing in peripheral sensory neurons mediated by voltage-gated sodium channels contribute to the pathophysiology of chronic pain. Sodium channel blockers are, therefore, appealing entities for therapeutic intervention in painful human neuropathies. This review will focus on the latest advances in the development of small molecule sodium channel blockers and their application to the treatment of chronic pain.
Keywords: Sodium channel, voltage-gated, blocker, selective, pain
Current Topics in Medicinal Chemistry
Title: Voltage-Gated Sodium Channel Blockers for the Treatment of Chronic Pain
Volume: 9 Issue: 4
Author(s): Mark A. Matulenko, Marc J. C. Scanio and Michael E. Kort
Affiliation:
Keywords: Sodium channel, voltage-gated, blocker, selective, pain
Abstract: The voltage-gated sodium channels are a family of proteins that control the flow of sodium ions across cell membranes. Considerable data support the hypothesis that hyperexcitability and spontaneous action potential firing in peripheral sensory neurons mediated by voltage-gated sodium channels contribute to the pathophysiology of chronic pain. Sodium channel blockers are, therefore, appealing entities for therapeutic intervention in painful human neuropathies. This review will focus on the latest advances in the development of small molecule sodium channel blockers and their application to the treatment of chronic pain.
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Cite this article as:
Matulenko A. Mark, Scanio J. C. Marc and Kort E. Michael, Voltage-Gated Sodium Channel Blockers for the Treatment of Chronic Pain, Current Topics in Medicinal Chemistry 2009; 9 (4) . https://dx.doi.org/10.2174/156802609788317883
DOI https://dx.doi.org/10.2174/156802609788317883 |
Print ISSN 1568-0266 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4294 |
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