Abstract
Attributed to the extensive researches towards the functions of Kv1.5 gene (also known as KCN5A gene), the therapeutic significances of Kv1.5 channel have been paid special attentions to cardiovascular diseases as well as tumor, the top two public-health problems for the aging population. During recent years, the hindrance for developing cardiovascular drugs is how to discriminate their therapeutic effect from cardiotoxicities. Therefore, targeting Kv1.5 gene, which encodes the atrial selective IKur potassium channel, has been confirmed as an appealing strategy for the treatment of atrial diseases. Moreover, the functions of Kv1.5 gene in carcinoma progression have also provoked a flurry of research in the hope of developing adjunctive or combined treatment of Kv1.5 modulators to enhance curative effects of classic chemotherapeutic agents.
Keywords: Atrial diseases, cardiac, cardiotoxicities, chemotherapeutic, IKur potassium channel, Kv1.5, tumor, ultra-rapid delayed rectifier
Current Topics in Medicinal Chemistry
Title: Drug Discoveries Towards Kv1.5 Potassium Channel
Volume: 9 Issue: 4
Author(s): Qian Yang, Xiaojian Wang, Lupei Du, Minyong Li and Qidong You
Affiliation:
Keywords: Atrial diseases, cardiac, cardiotoxicities, chemotherapeutic, IKur potassium channel, Kv1.5, tumor, ultra-rapid delayed rectifier
Abstract: Attributed to the extensive researches towards the functions of Kv1.5 gene (also known as KCN5A gene), the therapeutic significances of Kv1.5 channel have been paid special attentions to cardiovascular diseases as well as tumor, the top two public-health problems for the aging population. During recent years, the hindrance for developing cardiovascular drugs is how to discriminate their therapeutic effect from cardiotoxicities. Therefore, targeting Kv1.5 gene, which encodes the atrial selective IKur potassium channel, has been confirmed as an appealing strategy for the treatment of atrial diseases. Moreover, the functions of Kv1.5 gene in carcinoma progression have also provoked a flurry of research in the hope of developing adjunctive or combined treatment of Kv1.5 modulators to enhance curative effects of classic chemotherapeutic agents.
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Cite this article as:
Yang Qian, Wang Xiaojian, Du Lupei, Li Minyong and You Qidong, Drug Discoveries Towards Kv1.5 Potassium Channel, Current Topics in Medicinal Chemistry 2009; 9 (4) . https://dx.doi.org/10.2174/156802609788317810
DOI https://dx.doi.org/10.2174/156802609788317810 |
Print ISSN 1568-0266 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4294 |
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